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Onco Checklist >> CLL Staging

 


DiagnosisResult
Peripheral blood smears 
Immunophenotyping 
p53-mutation 
IgVH-mutation status 
FISH 
Bone marrow biopsy (only in selected  cases) 


Patient historyResult
 Weight loss (>10% in 6 months) 
 Night sweats (with changing of clothes) 
 Fever (>38°C) with no other cause 
 Itching 
 Lymphocyte doubling time 


Physical examinationResult
 Lymph nodes, heart-/lung, abdominal examination, edemas? Skin changes?
Size of spleen / liver (palpable below ribs?)
 
 Height and weight 
 Blood pressure and frequency 



Clinical chemistryResult
Blood count
Electrolytes
Creatinine
Creatinine clearance (calculated)
Liver enzymes (AST; ALT; G-GT)
Bilirubine
ESR
AP
Coagulation parameters (incl. ATIII, D-dimers, fibrinogen)
LDH
CRP
Elektrophoresis, IgG, IgA, IgM (deficiency?)
 
Beta-2-mikroglobuline 
Tyrosine kinase
 


VirologyResult
 HIV 1 and 2  
 Hepatitis B 
 Hepatitis C 
 EBV (?)
 



Imaging and other examintationsResult
Chest X-ray 
Sonography of abdomen 
CT of thorax and abdomen (if necessary for staging of lymph adenopathy) 
Echocardiography 
Spirometry 
EKG 


StudiesResult
 Inclusion in study possible? yes no
 Study: 



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